SETD7 anticorps

N° du produit ABIN7118988

Cet anticorps anti-SETD7 est un anticorps Lapin Polyclonal détectant SETD7 dans WB et ELISA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour SETD7 anticorps (ABIN7118988)

Antigène: SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SETD7 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-SETD7 anticorps

Fonction: SETD7 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: SET domain containing(lysine methyltransferase) 7

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur SETD7

Antigène: SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))

Autre désignation: SETD7

Sujet:

Synonyms: Histone-lysine N-methyltransferase SETD7|Histone H3-K4 methyltransferase SETD7 (H3-K4-HMTase SETD7)|Lysine N-methyltransferase 7|SET domain-containing protein 7|SET7/9|SETD7|KIAA1717|KMT7|SET7|SET9

Background: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

Poids moléculaire: 48-50 kDa

ID gène: 80854

UniProt: Q8WTS6